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                            | Cytology |   
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                            | Cytology 
                                means "the study of cells". Cytology 
                                is that branch of life science, which deals with 
                                the study of cells in terms of structure, function 
                                and chemistry. Robert Hooke is considered as the 
                                father of cytology.
 YEAR…………..SCIENTIST…………………….DISCOVERY
 1590…. Z. Janssen & H. Janssen…. 
                                Produced the 1st operational compound microscope.
 1665..…..Robert Hooke………..…Observed 
                                dead cork cells and introduced the term “cell” 
                                to describe them
 1674…………Anton Von Leeuwenhoek……..Discovered 
                                the first living cell which was a protozoa.
 1675…….Anton Von Leeuwenhoek…. 
                                Discovered a bacteria
 1831…………Robert Brown……………. 
                                Discovered nucleus
 1833………. Robert Brown…………….Discovered 
                                the cell nucleus in the flowering plant Tradescantia
 1835……………Felix Dujardin……………Described 
                                protoplasm in protozoa & considered it to 
                                be living matter.
 1838 - 1839……………The 
                                botanist Jakob Matthias Schleiden (in 1838) and 
                                the biologist Theodor Schwann……………proposed 
                                the cell theory. The cell theory states that the 
                                cells are the fundamental particles of both plants 
                                and animals, the cell retains a dual existence 
                                as a distinct entity and as a building block and 
                                the cells are formed by spontaneous generation
 
 
  
                                1839……………J.E 
                                  Purkinje……………proposed 
                                  the name protoplasm1844……………Hans 
                                  Christian Gram……………devised 
                                  the gram staining method
 1848…………… Hofmeister……………saw 
                                  the Chromosomes first
 1850……………Kolliker…………… 
                                  Describes mitochondria in muscle
 1855……………Rudolph 
                                  Virchow…………… modified 
                                  the third statement of cell theory & stated 
                                  that all cells arise from pre- existing cells
 1862……………Albrecht 
                                  Kolliker……………introduced 
                                  the term cytoplasm
 1866……………Ernst 
                                  Haeckel…………… established 
                                  that the nucleus was responsible for storing 
                                  & transmitting hereditary characters
 1874……………Fontana…………… 
                                  discovered nucleolus
 1875……………Van Beneden…………… 
                                  observed the centriole
 1879…………… W. Flemming…………… 
                                  observed Cell division first in salamander
 1882……………W. Flemming 
                                  coined the term mitosis
 1882……………Robert 
                                  Koch…………… uses 
                                  aniline dyes to identify bacteria causing TB 
                                  & cholera
 1887…………… Weismann…………… 
                                  Discovered meiosis
 1888…………… w. Waldeyer…………… 
                                  saw Darkly stained rod like structures during 
                                  nuclear division and called it chromosomes
 1888…………… Theodor 
                                  Boveri…………… termed 
                                  the complex formed of centriole & centrosphere 
                                  as centrosome
 1898……………Camilo 
                                  Golgi…………… stains 
                                  cell with silver nitrate, discovering the Golgi 
                                  apparatus
 1899……………Altmann…………… 
                                  introduced the term nucleic acid
 1901-1903……………W.LJohannsen…………… 
                                  coined the word gene.
 1905…………… J.B 
                                  Farmer…………… coined 
                                  the term meiosis which means to reduce or diminish
 1924……………R.Feulgen 
                                  & H.Rossenbeck…………… 
                                  described a test for the presence of DNA
 1929……………K.Lohmann 
                                  discovered ATP, the source of energy in biochemical 
                                  reactions.
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                            | 1931……………Ernst 
                                Ruska ……………builds 
                                first transmission electron microscope organelles.1935……………James 
                                Danielli & Hugh Davson…………… 
                                were the first to propose a molecular model of 
                                the plasma membrane1944……………Keith Porter 
                                & Albert Claude…………… 
                                took the first picture of an intact cell with 
                                the electron microscope.
 1944……………O.T Avery, 
                                C.M Mc Loed & M. Mc Carty…………… 
                                showed the significance of DNA as the hereditary 
                                material by studies of transformation in bacteria.
 1945……………Keith Porter 
                                used the term endoplasmic reticulum to identify 
                                a fine reticulum in endoplasm of the cell.
 1953……………J.D Watson 
                                & F.H.C Crick proposed a model for the DNA 
                                molecule
 1953 February 28……………Watson 
                                and Crick…………… made 
                                their first announcement on the double-helix structure 
                                for DNA
 1955……………Christian 
                                de Duve…………… discovered 
                                lysosome
 1955……………Palade…………… 
                                discovered Ribosome
 1957……………Seymour 
                                Benzer…………… gave 
                                the concept of cistron, the functional unit of 
                                gene
 1959…………… Robertson…………… 
                                coined the name plasma membrane
 1972……………S. Jonathan 
                                Singer & Garth Nicholson…………… 
                                proposed the fluid mosaic model for plasma membrane. 
                                According to this model, the membrane is a continuous 
                                bi lipid layer having integrated protein molecules.
 1981……………Lynn Margulis…………… 
                                published Symbiosis in Cell Evolution detailing 
                                the endosymbiotic theory.1989……………C.Benda…………… 
                                introduced the term mitochondria
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